| Keanu Reeves | Neo |
| Laurence Fishburne | Morpheus |
| Carrie-Anne Moss | Trinity |
| Hugo Weaving | Agent Smith |
| Gloria Foster | Oracle |
| Joe Pantoliano | Cypher |
| Marcus Chong | Tank |
| Julian Arahanga | Apoc |
| Matt Doran | Mouse |
| Belinda McClory | Switch |
| Anthony Ray Parker | Dozer |
| Paul Goddard | Agent Brown |
| Robert Taylor | Agent Jones |
| David Aston | Rhineheart |
| Marc Gray | Choi |
| Ada Nicodemou | Dujour |
| Denni Gordon | Priestess |
| Rowan Witt | Spoon Boy |
| Elenor Witt | Potential |
| Tamara Brown | Potential |
| Janaya Pender | Potential |
| Adryn White | Potential |
| Natalie Tjen | Potential |
| Bill Young | Lieutenant |
| David O'Connor | FedEx Man |
| Jeremy Ball | Businessman |
| Fiona Johnson | Woman in Red |
| Harry Lawrence | Old Man |
| Steve Dodd | Blind Man |
| Luke Quinton | Security Guard |
| Lawrence Woodward | Guard |
| Michael Butcher | Cop Who Captures Neo |
| Bernard Ledger | Big Cop |
| Robert Simper | Cop |
| Chris Scott | Cop |
| Nigel Harbach | Parking Cop |
| Kevin Michael Richardson | Thadeus |
| Pamela Segall | Jue |
| John Di Maggio | Crew Man |
| Tom Kenny | Operator |
| Rick Gomez | Pilot |
| Tara Strong | Crew Woman |
| Bette Ford | Old Woman |
| Geofrey Darrow | Conceptual Designer |
| Dane A. Davis | Sound Designer |
| Don Davis | Composer |
| Lorenzo DiBonaventura | President, Worldwide Theatrical Production, Warner Bros. |
| Peter Doyle | Dfilm |
| Laurence Fishburne | Himself/Morpheus |
| John Gaeta | Visual Effects Supervisor |
| Owen Paterson | Production Designer |
| Bill Pope | Director of Photography |
| Jason Bentley | Music Supervisor |
| Keanu Reeves | Himself/Neo |
| Joel Silver | Producer |
| Janek Sirrs | Associate VFX Supervisor |
| Steve Skroce | Storyboard Artist |
| Zach Staenberg | Editor |
| Andy Wachowski | Himself/Director |
| Larry Wachowski | Himself/Director |
| Hugo Weaving | Himself/Agent Smith |
| Woo-ping Yuen | Kung Fu Choreographer |
| Kym Barrett | Costume Designer |
| Carrie-Anne Moss | Herself |
| Mary Alice | The Oracle |
| Tanveer K. Atwal | Sati |
| Helmut Bakaitis | The Architect |
| Kate Beahan | Coat Check Girl |
| Francine Bell | Councillor Grace |
| Monica Bellucci | Persephone |
| Rachel Blackman | Charra |
| Henry Blasingame | Deus Ex Machina |
| Ian Bliss | Bane |
| David Bowers | Q-Ball Gang Member #1 |
| Zeke Castelli | Operations Officer Mattis |
| Sing Ngai | Seraph |
| Essie Davis | Maggie |
| Laurence Fishburne | Morpheus |
| Nona M. Gaye | Zee |
| Dion Horstmans | Q-Ball Gang Member #2 |
| Lachy Hulme | Sparks |
| Christopher Kirby | Mauser |
| Peter Lamb | Colt |
| Nathaniel Lees | Mifune |
| Harry J. Lennix | Lock |
| Robert Mammone | AK |
| Joe Manning | First Operator at Command |
| Maurice Morgan | Tower Soldier |
| Carrie-Anne Moss | Trinity |
| Tharini Mudaliar | Kamala |
| Rene Naufahu | Zion Gate Operator |
| Robyn Nevin | Councillor Dillard |
| Genevieve O'Reilly | Officer Wirtz |
| Harold Perrineau Jr | .Link |
| Jada Pinkett Smith | Niobe |
| Kittrick Redmond | Second Operator at Command |
| Keanu Reeves | Neo |
| Rupert Reid | Lock's Lieutenant |
| Kevin Michael Richardson | Deus Ex Machina |
| David Roberts | Roland |
| Bruce Spence | Trainman |
| Richard Sydenham | Dock Sergeant |
| Che Timmins | Radio Bunker Man |
| Gina Torres | Cas |
| Clayton Watson | Kid |
| Hugo Weaving | Agent Smith |
| Cornel West | Councillor West |
| Bernard White | Rama-Kandra |
| Lambert Wilson | Merovingian |
| Anthony Wong | Ghost |
| Anthony Zerbe | Councillor Hamann |
| Ray Anthony | Power Station Guard |
| Christine Anu | Kali |
| Andy Arness | Police #2 |
| Alima Ashton-Sheibu | Link's Niece |
| Helmut Bakaitis | The Architect |
| Steve Bastoni | Soren |
| Don Battee | Vector |
| Monica Bellucci | Persephone |
| Daniel Bernhardt | Agent Johnson |
| Valerie Berry | Priestess |
| Ian Bliss | Bane |
| Liliana Bogatko | Old Woman at Zion |
| Michael Budd | Zion Controller |
| Stoney Burke | Bike Carrier Driver |
| Kelly Butler | Ice |
| Josephine Byrnes | Zion Virtual Control Operator |
| Noris Campos | Woman with Groceries |
| Sing Ngai | Seraph |
| Paul Cotter | Corrupt |
| Marlene Cummins | Another Old Woman at Zion |
| Attila Davidhazy | Young Thomas Anderson at 12 |
| Essie Davis | Maggie |
| Terrell Dixon | Wurm |
| Nash Edgerton | Security Guard #5 |
| Laurence Fishburne | Morpheus |
| Gloria Foster | The Oracle |
| David Franklin | Maitre D' |
| Austin Galuppo | Young Thomas Anderson at 4 |
| Nona M. Gaye | Zee |
| Daryl Heath | A.P.U. Escort |
| Roy Jones Jr | .Ballard |
| Malcolm Kennard | Abel |
| David Kilde | Agent Jackson |
| Randall Duk Kim | The Keymaker |
| Christopher Kirby | Mauser |
| Peter Lamb | Colt |
| Nathaniel Lees | Mifune |
| Harry J. Lennix | Commander Lock |
| Tony Lynch | Computer Room Technician |
| Robert Mammone | AK |
| Joshua Mbakwe | Link's Nephew |
| Matt McColm | Agent Thompson |
| Scott McLean | Security Bunker Guard #2 |
| Chris Mitchell | Power Station Guard |
| Steve Morris | Computer Room Guard |
| Carrie-Anne Moss | Trinity |
| Tory Mussett | Beautiful Woman at Le Vrai |
| Rene Naufahu | Zion Gate Operator |
| Robyn Nevin | Councillor Dillard |
| David No | Cain |
| Genevieve O'Reilly | Officer Wirtz |
| Socratis Otto | Operator |
| Harold Perrineau Jr | .Link |
| Jada Pinkett Smith | Niobe |
| Montaño Rain | Young Thomas Anderson at 8 |
| Adrian Rayment | Twin #2 |
| Neil Rayment | Twin #1 |
| Rupert Reid | Lock's Lieutenant |
| Keanu Reeves | Neo |
| David Roberts | Roland |
| Shane C. Rodrigo | Ajax |
| Nick Scoggin | Gidim Truck Driver |
| Kevin Scott | 18 Wheel Trucker |
| Tahei Simpson | Binary |
| Frankie Stevens | Tirant |
| Nicandro Thomas | Young Thomas Anderson at 2 |
| Gina Torres | Cas |
| Andrew Valli | Police #1 |
| Steve Vella | Malachi |
| John Walton | Security Bunker Guard |
| Clayton Watson | Kid |
| Hugo Weaving | Agent Smith |
| Cornel West | Councillor West |
| Leigh Whannell | Axel |
| Bernard White | Rama-Kandra |
| Lambert Wilson | Merovingian |
| Anthony Wong | Ghost |
| Anthony Zerbe | Councillor Hamann |
| Clayton Watson | Michael Karl Popper AKA The Kid (segment "Kid's Story") |
| Akio Ôtsuka | Thadeus (Japanese version) |
| Dane A. Davis | 01 Versatran Spokesman (segment "The Second Renaissance, Part II") |
| John DeMita | Teacher (segment "Kid's Story") |
| John Di Maggio | Crew Man (segment "Final Flight of the Osiris")/Kaiser (segment "Program") |
| Alex Fernández | Tom (segment "World Record") |
| Jack Fletcher | Townsperson (segment "Beyond")/Sandro (segment "Matriculated") |
| Rick Gomez | Pilot (segment "Final Flight of the Osiris") |
| Tom Kenny | Operator (segment "Final Flight of the Osiris") |
| Phil LaMarr | Duo (segment "Program") |
| Matt McKenzie | Agent #1 (segment "World Record")/Agent (segments "Beyond" and "A Detective Story") |
| Keanu Reeves | Neo (segment "Kid's Story") |
| Kevin Michael Richardson | Thadeus (segment "Final Flight of the Osiris")/Cop (segment "Kid's Story")/Agent #2 (segment "World Record") |
| Rodney Saulsberry | Chyron (segment "Matriculated") |
| Dwight Schultz | Townspeople, Policeman, Exterminators (segment "Beyond")/Nonaka (segment "Matriculated")/Additional voice (segments "The Second Renaissance, Part I&II") |
| James Arnold Taylor | Additional voice (segments "The Second Renaissance, Parts I&II)/Miscellaneous (segment "Kid's Story")/Ash (segment "A Detective Story")/Raul (segment "Matriculated") |
| John Wesley | Dan's Dad (segment "World Record") |
| Victor Williams | Dan (segment "World Record") |
| Terrence 'T.C.' Carson | Clarence |
| Tress MacNeille | Housewife/Kenny (segment "Beyond") |
| Carrie-Anne Moss | Trinity (segments "Kid's Story" and "A Detective Story") |
| Pamela Segall | Jue (segment "Final Flight of the Osiris")/Manabu (segment "Beyond") |
| Allison Smith | Reporter (segment "World Record") |
| Kath Soucie | Pudgy/Masa/Sara (segment "Beyond") |
| Tara Strong | Crew Woman (segment "Final Flight of the Osiris")/Nurse (segment "World Record")/Misha (segment "Beyond") |
| Jill Talley | Mother/Additional voice (segments "The Second Renaissance, Parts I&II")/Townsperson (segment "Beyond") |
| Olivia d'Abo | Rox (segment "Matriculated") |
| Hedy Burress | Cis (segment "Program")/Yoko (segment "Beyond") |
| Melinda Clarke | Alexa (segment "Matriculated") |
| Debi Derryberry | Kid (segment "The Second Renaissance, Part II") |
| Julia Fletcher | The Instructor (segments "The Second Renaissance, Parts I&II")/Narrator (segment "World Record")/Townsperson (segment "Beyond") |
| Bette Ford | Old Woman (segment "Final Flight of the Osiris") |
