| Ben Affleck | Capt. Rafe McCawley |
| Josh Hartnett | Capt. Danny Walker |
| Kate Beckinsale | Nurse Lt. Evelyn Johnson |
| Cuba Gooding Jr | .Petty Officer Doris 'Dorie' Miller |
| Jon Voight | President Franklin Delano Roosevelt |
| Alec Baldwin | Lt. Col. James 'Jimmy' Doolittle |
| Tom Sizemore | Sgt. Earl Sistern |
| William Lee Scott | Lt. Billy Thompson |
| Greg Zola | Lt. Anthony Fusco |
| Ewen Bremner | Lt. Red Winkle |
| Jaime King | Nurse Betty Bayer |
| Catherine Kellner | Nurse Barbara |
| Jennifer Garner | Nurse Sandra |
| Sara Rue | Nurse Martha |
| Michael Shannon | Lt. Gooz Wood |
| Dan Aykroyd | Capt. Thurman |
| Colm Feore | Adm. Husband E. Kimmel |
| John Fujioka | Nishikura |
| Mako | Adm. Isoruku Yamamoto |
| Cary-Hiroyuki Tagawa | Cmdr. Mirou Genda |
| Matthew Davis | Joe |
| Reiley McClendon | Young Danny |
| Jesse James | Young Rafe |
| William Fichtner | Danny's father |
| Steve Rankin | Rafe's father |
| Brian Haley | Training captain |
| David Hornsby | Flyer with murmur |
| Scott Wilson | Gen. George C. Marshall |
| Graham Beckel | Adm. Chester W. Nimitz |
| Howard Mungo | George |
| Randy Oglesby | Strategic analyst |
| Ping Wu | Japanese officer |
| Stan Cahill | Pentagon lieutenant |
| Kevin Wensing | Executive Officer, USS West Virginia |
| Tom Everett | Secretary of the Navy Frank Knox |
| Tomas Arana | Vice-Adm. Frank J. 'Jack' Fletcher |
| Beth Grant | Motherly secretary |
| Sung Kang | Listener |
| Raphael Sbarge | Kimmel's aide |
| Marty Belafsky | Louie (sailor) |
| Yuji Okumoto | Japanese shy bomber |
| Josh Green | Pvt. Ellis (radar operator) |
| Ian Bohen | Radar private #2 |
| Michael Milhoan | Army commander |
| Peter Firth | Capt. Mervyn Bennion (USS West Virginia) |
| Marco Gould | Pop-up sailor |
| Andrew Bryniarski | Joe (boxer) |
| Nicholas Downs | Terrified sailor |
| Tim Choate | Navy doctor |
| John Diehl | Senior doctor |
| Joseph Patrick Kelly | Medic |
| Ron Harper | Minister |
| Ted McGinley | Army major |
| Madison Mason | Adm. Raymond A. Spruance |
| Kim Coates | Jack Richards |
| Andrew Baley | Hornet radio op |
| Glenn Morshower | RAdm. William F. 'Bull' Halsey Jr. |
| Paul Francis | Doolittle co-pilot |
| Scott Wiper | Gunner |
| Eric Christian Olsen | Gunner |
| Rod Biermann | Navigator |
| Noriaki Kamata | Japanese soldier |
| Garret Sato | Japanese soldier |
| Eiji Inoue | Japanese soldier |
| Precious Chong | Nursing supervisor |
| Jeff Wadlow | Next guy in line |
| Will Gill Jr | .Train conductor |
| Seth Sakai | Japanese tourist |
| Curtis Andersen | 18-year-old typist |
| Blaine Pate | Orderly in aftermath |
| John Pyper-Ferguson | Naval officer in hospital |
| Michael Shamus Wiles | Captain of the Hornet |
| Brett Pedigo | Next guy in line #2 |
| Toru Tanaka Jr | .Samoan bouncer |
| Sean Gunn | Traction sailor |
| Josh Ackerman | Wounded sailor #1 |
| Matt Casper | Wounded sailor #2 |
| David Kaufman | Young nervous doctor |
| Lindsey Ginter | Capt. Low |
| Joshua Aaron Gulledge | Buster |
| Guy Torry | Teeny Mayfield |
| Leland Orser | Maj. Jackson |
| Peter James Smith | Mission listener |
| Mark Noon | Medic |
| Pat Healy | Newsreel guy |
| Thomas Wilson Brown | Young Flier |
| Chad Morgan | Pearl Harbor Nurse |
| James Saito | Japanese Aide #1 |
| Angel Sing | Japanese Aide #2 |
| Tak Kubota | Japanese Aide #3 |
| Robert Jayne | Sunburnt Sailor |
| Vic Chao | Japanese Doctor |
| Michael Gradilone | Screaming Sailor |
| Frederick Koehler | Wounded Sailor #3 |
| John Padget | Hospital Chaplain |
| Ben Easter | Baja Sailor #1 |
| Cory Tucker | Baja Sailor #2 |
| Abe Sylvia | Baja Sailor #4 |
| Jason Liggett | Baja Sailor #5 |
| Mark Panasuk | Baja Sailor #6 |
| Bret Roberts | Baja Sailor #7 |
| John Howry | Lieutenant in Boat |
| Rufus Dorsey | Dorie's Friend |
| Patrice Martinez | French Fisherman |
| Rodney Bursiel | Sailor with Dog |
| Rob McCabe | Rescue Sailor |
| Brandon Lozano | Baby Danny |
| Seiki Moriguchi | Akagi Communication Officer |
| Brian D. Falk | Helmsman #1 |
| Estevan Gonzalo | Bombing Sailor |
| Christopher Stroop | Helmsman #2 |
| Sean Faris | Danny's Gunner |
| Vincent J. Inghilterra | Preacher |
| Nicholas Farrell | RAF Squadron Leader |
| Tony Curran | Ian |
| Viv Weatherall | Pilot #1 |
| Benjamin Farry | Pilot #2 |
| Daniel Mays | Pilot #3 |
| Toshi Toda | Dentist |
| Jaymee Ong | Dental Assistant |
| Jeremy Denzlinger | Sailor |
| Jeremy Gilbreath | Toothbrush Sailor |
| Ken Goth | Army 2nd Lieutenant |
| Geoffrey Gould | Dental Patient |
| Anthony Grimley | British Air Commander Peter Tubbs |
| Hank Harris | Young Harbor Patrolman |
| Adolf Hitler | Himself |
| Manu Intiraymi | Officer in water shouting "P-40's" |
| Greg Baine | Young Sailor |
| Saburo Kurusu | Himself (in Washington with Nomura) |
| Robert C. Nelson | Army Officer |
| Kichisaburo Nomura | Himself (in Washington with Kurusu) |
| Lin Oeding | Japanese Sailor |
| Pete Romano | Soldier in the Water |
| David Rountree | Navy Pilot |
| Leway Shih | Japanese Airplane Mechanic |
| Lijay Shih | Japanese Airplane Pilot |
| Jack Truman | Train Conductor |
| Clyde Tull | Army Officer |
| Larry Wegger | Taxi Driver |
| Mark Weiler | Naval Messenger |
| James Yeung | Japanese Sailor |
| David de Vos | Medical Orderly |
| Wally Burr | Newsreel Voice |
| Winston Churchill | Himself |
| Frieda Jane | Nurse |
| Elizabeth Leaff | Nurse |
| Annika Banko | Extra |
| Kathleen Mullan | Stearn Nurse |
| Naoko Niya | Hawaiian Bar Girl |
| Lisa Ross | Nurse |
| Barbara Scolaro | Mrs. Doolittle |
